Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients.
Identifieur interne : 000228 ( Main/Exploration ); précédent : 000227; suivant : 000229Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients.
Auteurs : M. Fernández-Ruiz [Espagne] ; I. Corrales ; M. Arias ; J M Campistol ; E. Giménez ; J. Crespo ; M O L Pez-Oliva ; I. Beneyto ; P L Martín-Moreno ; F. Llamas-Fuente ; A. Gutiérrez ; T. García-Álvarez ; R. Guerra-Rodríguez ; N. Calvo ; A. Fernández-Rodríguez ; J M Tabernero-Romo ; M D Navarro ; A. Ramos-Verde ; J M Aguado ; D. NavarroSource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Alleles, Cell Adhesion Molecules (genetics), Cytomegalovirus Infections (blood), Cytomegalovirus Infections (genetics), Female, Genotype, Humans, Immunity, Innate (genetics), Incidence, Interleukins (genetics), Kidney Failure, Chronic (blood), Kidney Failure, Chronic (genetics), Kidney Failure, Chronic (surgery), Kidney Transplantation, Lectins, C-Type (genetics), Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prospective Studies, Receptors, Cell Surface (genetics), Transplant Recipients.
- MESH :
- chemical , genetics : Cell Adhesion Molecules, Interleukins, Lectins, C-Type, Receptors, Cell Surface.
- blood : Cytomegalovirus Infections, Kidney Failure, Chronic.
- genetics : Cytomegalovirus Infections, Immunity, Innate, Kidney Failure, Chronic.
- surgery : Kidney Failure, Chronic.
- Adult, Aged, Alleles, Female, Genotype, Humans, Incidence, Kidney Transplantation, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prospective Studies, Transplant Recipients.
Abstract
In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.
DOI: 10.1111/ajt.13107
PubMed: 25777542
Affiliations:
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Le document en format XML
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Corrales</name></author><author><name sortKey="Arias, M" sort="Arias, M" uniqKey="Arias M" first="M" last="Arias">M. Arias</name></author><author><name sortKey="Campistol, J M" sort="Campistol, J M" uniqKey="Campistol J" first="J M" last="Campistol">J M Campistol</name></author><author><name sortKey="Gimenez, E" sort="Gimenez, E" uniqKey="Gimenez E" first="E" last="Giménez">E. Giménez</name></author><author><name sortKey="Crespo, J" sort="Crespo, J" uniqKey="Crespo J" first="J" last="Crespo">J. Crespo</name></author><author><name sortKey="L Pez Oliva, M O" sort="L Pez Oliva, M O" uniqKey="L Pez Oliva M" first="M O" last="L Pez-Oliva">M O L Pez-Oliva</name></author><author><name sortKey="Beneyto, I" sort="Beneyto, I" uniqKey="Beneyto I" first="I" last="Beneyto">I. Beneyto</name></author><author><name sortKey="Martin Moreno, P L" sort="Martin Moreno, P L" uniqKey="Martin Moreno P" first="P L" last="Martín-Moreno">P L Martín-Moreno</name></author><author><name sortKey="Llamas Fuente, F" sort="Llamas Fuente, F" uniqKey="Llamas Fuente F" first="F" last="Llamas-Fuente">F. Llamas-Fuente</name></author><author><name sortKey="Gutierrez, A" sort="Gutierrez, A" uniqKey="Gutierrez A" first="A" last="Gutiérrez">A. Gutiérrez</name></author><author><name sortKey="Garcia Lvarez, T" sort="Garcia Lvarez, T" uniqKey="Garcia Lvarez T" first="T" last="García-Álvarez">T. García-Álvarez</name></author><author><name sortKey="Guerra Rodriguez, R" sort="Guerra Rodriguez, R" uniqKey="Guerra Rodriguez R" first="R" last="Guerra-Rodríguez">R. Guerra-Rodríguez</name></author><author><name sortKey="Calvo, N" sort="Calvo, N" uniqKey="Calvo N" first="N" last="Calvo">N. Calvo</name></author><author><name sortKey="Fernandez Rodriguez, A" sort="Fernandez Rodriguez, A" uniqKey="Fernandez Rodriguez A" first="A" last="Fernández-Rodríguez">A. Fernández-Rodríguez</name></author><author><name sortKey="Tabernero Romo, J M" sort="Tabernero Romo, J M" uniqKey="Tabernero Romo J" first="J M" last="Tabernero-Romo">J M Tabernero-Romo</name></author><author><name sortKey="Navarro, M D" sort="Navarro, M D" uniqKey="Navarro M" first="M D" last="Navarro">M D Navarro</name></author><author><name sortKey="Ramos Verde, A" sort="Ramos Verde, A" uniqKey="Ramos Verde A" first="A" last="Ramos-Verde">A. Ramos-Verde</name></author><author><name sortKey="Aguado, J M" sort="Aguado, J M" uniqKey="Aguado J" first="J M" last="Aguado">J M Aguado</name></author><author><name sortKey="Navarro, D" sort="Navarro, D" uniqKey="Navarro D" first="D" last="Navarro">D. Navarro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25777542</idno><idno type="pmid">25777542</idno><idno type="doi">10.1111/ajt.13107</idno><idno type="wicri:Area/PubMed/Corpus">000100</idno><idno type="wicri:Area/PubMed/Curation">000100</idno><idno type="wicri:Area/PubMed/Checkpoint">000118</idno><idno type="wicri:Area/Ncbi/Merge">000D24</idno><idno type="wicri:Area/Ncbi/Curation">000D24</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D24</idno><idno type="wicri:Area/Main/Merge">000225</idno><idno type="wicri:Area/Main/Curation">000228</idno><idno type="wicri:Area/Main/Exploration">000228</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients.</title><author><name sortKey="Fernandez Ruiz, M" sort="Fernandez Ruiz, M" uniqKey="Fernandez Ruiz M" first="M" last="Fernández-Ruiz">M. Fernández-Ruiz</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre, Madrid</wicri:regionArea><wicri:noRegion>Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Corrales, I" sort="Corrales, I" uniqKey="Corrales I" first="I" last="Corrales">I. Corrales</name></author><author><name sortKey="Arias, M" sort="Arias, M" uniqKey="Arias M" first="M" last="Arias">M. Arias</name></author><author><name sortKey="Campistol, J M" sort="Campistol, J M" uniqKey="Campistol J" first="J M" last="Campistol">J M Campistol</name></author><author><name sortKey="Gimenez, E" sort="Gimenez, E" uniqKey="Gimenez E" first="E" last="Giménez">E. Giménez</name></author><author><name sortKey="Crespo, J" sort="Crespo, J" uniqKey="Crespo J" first="J" last="Crespo">J. Crespo</name></author><author><name sortKey="L Pez Oliva, M O" sort="L Pez Oliva, M O" uniqKey="L Pez Oliva M" first="M O" last="L Pez-Oliva">M O L Pez-Oliva</name></author><author><name sortKey="Beneyto, I" sort="Beneyto, I" uniqKey="Beneyto I" first="I" last="Beneyto">I. Beneyto</name></author><author><name sortKey="Martin Moreno, P L" sort="Martin Moreno, P L" uniqKey="Martin Moreno P" first="P L" last="Martín-Moreno">P L Martín-Moreno</name></author><author><name sortKey="Llamas Fuente, F" sort="Llamas Fuente, F" uniqKey="Llamas Fuente F" first="F" last="Llamas-Fuente">F. Llamas-Fuente</name></author><author><name sortKey="Gutierrez, A" sort="Gutierrez, A" uniqKey="Gutierrez A" first="A" last="Gutiérrez">A. Gutiérrez</name></author><author><name sortKey="Garcia Lvarez, T" sort="Garcia Lvarez, T" uniqKey="Garcia Lvarez T" first="T" last="García-Álvarez">T. García-Álvarez</name></author><author><name sortKey="Guerra Rodriguez, R" sort="Guerra Rodriguez, R" uniqKey="Guerra Rodriguez R" first="R" last="Guerra-Rodríguez">R. Guerra-Rodríguez</name></author><author><name sortKey="Calvo, N" sort="Calvo, N" uniqKey="Calvo N" first="N" last="Calvo">N. Calvo</name></author><author><name sortKey="Fernandez Rodriguez, A" sort="Fernandez Rodriguez, A" uniqKey="Fernandez Rodriguez A" first="A" last="Fernández-Rodríguez">A. Fernández-Rodríguez</name></author><author><name sortKey="Tabernero Romo, J M" sort="Tabernero Romo, J M" uniqKey="Tabernero Romo J" first="J M" last="Tabernero-Romo">J M Tabernero-Romo</name></author><author><name sortKey="Navarro, M D" sort="Navarro, M D" uniqKey="Navarro M" first="M D" last="Navarro">M D Navarro</name></author><author><name sortKey="Ramos Verde, A" sort="Ramos Verde, A" uniqKey="Ramos Verde A" first="A" last="Ramos-Verde">A. Ramos-Verde</name></author><author><name sortKey="Aguado, J M" sort="Aguado, J M" uniqKey="Aguado J" first="J M" last="Aguado">J M Aguado</name></author><author><name sortKey="Navarro, D" sort="Navarro, D" uniqKey="Navarro D" first="D" last="Navarro">D. Navarro</name></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="e-ISSN">1600-6143</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alleles</term><term>Cell Adhesion Molecules (genetics)</term><term>Cytomegalovirus Infections (blood)</term><term>Cytomegalovirus Infections (genetics)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Immunity, Innate (genetics)</term><term>Incidence</term><term>Interleukins (genetics)</term><term>Kidney Failure, Chronic (blood)</term><term>Kidney Failure, Chronic (genetics)</term><term>Kidney Failure, Chronic (surgery)</term><term>Kidney Transplantation</term><term>Lectins, C-Type (genetics)</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Receptors, Cell Surface (genetics)</term><term>Transplant Recipients</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cell Adhesion Molecules</term><term>Interleukins</term><term>Lectins, C-Type</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Immunity, Innate</term><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alleles</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Incidence</term><term>Kidney Transplantation</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Transplant Recipients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Aguado, J M" sort="Aguado, J M" uniqKey="Aguado J" first="J M" last="Aguado">J M Aguado</name><name sortKey="Arias, M" sort="Arias, M" uniqKey="Arias M" first="M" last="Arias">M. Arias</name><name sortKey="Beneyto, I" sort="Beneyto, I" uniqKey="Beneyto I" first="I" last="Beneyto">I. Beneyto</name><name sortKey="Calvo, N" sort="Calvo, N" uniqKey="Calvo N" first="N" last="Calvo">N. Calvo</name><name sortKey="Campistol, J M" sort="Campistol, J M" uniqKey="Campistol J" first="J M" last="Campistol">J M Campistol</name><name sortKey="Corrales, I" sort="Corrales, I" uniqKey="Corrales I" first="I" last="Corrales">I. Corrales</name><name sortKey="Crespo, J" sort="Crespo, J" uniqKey="Crespo J" first="J" last="Crespo">J. Crespo</name><name sortKey="Fernandez Rodriguez, A" sort="Fernandez Rodriguez, A" uniqKey="Fernandez Rodriguez A" first="A" last="Fernández-Rodríguez">A. Fernández-Rodríguez</name><name sortKey="Garcia Lvarez, T" sort="Garcia Lvarez, T" uniqKey="Garcia Lvarez T" first="T" last="García-Álvarez">T. García-Álvarez</name><name sortKey="Gimenez, E" sort="Gimenez, E" uniqKey="Gimenez E" first="E" last="Giménez">E. Giménez</name><name sortKey="Guerra Rodriguez, R" sort="Guerra Rodriguez, R" uniqKey="Guerra Rodriguez R" first="R" last="Guerra-Rodríguez">R. Guerra-Rodríguez</name><name sortKey="Gutierrez, A" sort="Gutierrez, A" uniqKey="Gutierrez A" first="A" last="Gutiérrez">A. Gutiérrez</name><name sortKey="L Pez Oliva, M O" sort="L Pez Oliva, M O" uniqKey="L Pez Oliva M" first="M O" last="L Pez-Oliva">M O L Pez-Oliva</name><name sortKey="Llamas Fuente, F" sort="Llamas Fuente, F" uniqKey="Llamas Fuente F" first="F" last="Llamas-Fuente">F. Llamas-Fuente</name><name sortKey="Martin Moreno, P L" sort="Martin Moreno, P L" uniqKey="Martin Moreno P" first="P L" last="Martín-Moreno">P L Martín-Moreno</name><name sortKey="Navarro, D" sort="Navarro, D" uniqKey="Navarro D" first="D" last="Navarro">D. Navarro</name><name sortKey="Navarro, M D" sort="Navarro, M D" uniqKey="Navarro M" first="M D" last="Navarro">M D Navarro</name><name sortKey="Ramos Verde, A" sort="Ramos Verde, A" uniqKey="Ramos Verde A" first="A" last="Ramos-Verde">A. Ramos-Verde</name><name sortKey="Tabernero Romo, J M" sort="Tabernero Romo, J M" uniqKey="Tabernero Romo J" first="J M" last="Tabernero-Romo">J M Tabernero-Romo</name></noCountry><country name="Espagne"><noRegion><name sortKey="Fernandez Ruiz, M" sort="Fernandez Ruiz, M" uniqKey="Fernandez Ruiz M" first="M" last="Fernández-Ruiz">M. Fernández-Ruiz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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